Cardiologia Ambulatoriale - Outpatient Cardiology
https://www.cardiologiaambulatoriale.eu/tessuto-adiposo-epicardico-epifenomeno-della-sindrome-metabolica-o-concausa-della-patologia-coronarica/
Export date: Sun Nov 1 4:09:07 2026 / +0000 GMT

Epicardial adipose tissue. Epiphenomenon of metabolic syndrome or player in coronary artery disease?


Tessuto adiposo epicardico. Epifenomeno della sindrome metabolica o concausa della patologia coronarica?
Roberto Salvia 1, Michele Vacca 2
1 Università degli Studi di Bari “Aldo Moro”
2 MedicalResearchCouncil – Human NutritionResearch&Institute of Metabolic Science, Cambridge, UK


Abstract


Il tessuto adiposo epicardico (EAT) è un deposito di adipe che si estende tra il miocardio e lo strato viscerale del pericardio. Il tessuto adiposo epicardico partecipa attivamente all'omeostasi del miocardio non solo collaborando al suo metabolismo, ma anche con una vivace secrezione paracrina (adipochine, citochine, e mediatori vasoattivi). Diversi studi epidemiologici hanno evidenziato una forte associazione tra EAT e patologie metaboliche e cardiache. Questa review si propone di spiegare questa associazione alla luce delle conoscenze molecolari ad oggi acquisite, con un occhio al futuro, riguardo a potenziali applicazioni diagnostiche e terapeutiche.


Parole chiave: Tessuto adiposo epicardico; Dislipidemia; Obesità; Sindrome metabolica; Rischio cardiovascolare.


Abstract


The epicardial adipose tissue (EAT) extends between the myocardium and the visceral layer of the pericardium. EAT actively participates to the homeostasis of the myocardium toward metabolic regulation and the paracrine secretion of adipokines, cytokines, and vasoactive mediators. Several epidemiological studies have shown a strong association between EAT and metabolic and cardiac diseases. This review aims to explain this association in the light of molecular knowledge acquired to date, proposing future diagnostic and therapeutic applications.


Key words: Epicardial adipose tissue; Dyslipidemia; Obesity; Metabolic Syndrome; Cardiovascular risk.








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